Brain Research

【Brain Research】介绍
英文名称:Brain Research
中文名称:Brain Research,

Brain Research is a peer-reviewed scientific journal focusing on several aspects of neuroscience. It publishes research reports and "minireviews". Full reviews are published in Brain Research Reviews instead. Both are edited by Floyd E. Bloom.

In 2006, four previously established semi-independent journal sections (Cognitive Brain Research, Developmental Brain Research, Molecular Brain Research, and Brain Research Protocols) were merged with Brain Research.

The journal has nine main subsections:

    * Cellular and Molecular Biology of Nervous Systems
    * Nervous System Development, Regeneration and Aging
    * Neurophysiology, Neuropharmacology and other forms of Intercellular Communication
    * Structural Organization of the Brain
    * Sensory and Motor Systems
    * Regulatory Systems
    * Cognitive and Behavioral Neuroscience
    * Disease-Related Neuroscience
    * Computational and Theoretical Neuroscience

  1. Abnormal gene expression in cerebellum of Npc1-/- mice during postnatal development.

  2. Brain Research,2010 Apr 14;1325:128-40. Epub 2010 Feb 12

    Liao G, Wen Z, Irizarry K, Huang Y, Mitsouras K, Darmani M, Leon T, Shi L, Bi X.

    Zhining Wen 


    Niemann-Pick Type C (NPC) disease is an autosomal recessive neurodegenerative disorder with abnormal lipid storage as the major cellular pathologic hallmark. Genetic analyses have identified mutations in NPC1 gene in the great majority of cases, while mutations in NPC2 account for the remainders. Yet little is known regarding the cellular mechanisms responsible for NPC pathogenesis, especially for neurodegeneration, which is the usual cause of death. To identify critical steps that could account for the pathological manifestations of the disease in one of the most affected brain structures, we performed global gene expression analysis in the cerebellum from 3-week old Npc1+/+ and Npc1-/- mice with two different microarray platforms (Agilent and Illumina). Differentially expressed genes identified by both microarray platforms were then subjected to KEGG pathway analysis. Expression of genes in six pathways was significantly altered in Npc1-/- mice; functionally, these signaling pathways belong to the following three categories: (1) steroid and terpenoid biosynthesis, (2) immune response, and (3) cell adhesion/motility. In addition, the expression of several proteins involved in lipid transport was significantly altered in Npc1-/- mice. Our results provide novel molecular insight regarding the mechanisms of pathogenesis in NPC disease and reveal potential new therapeutic targets.