Computational biology and Chemistry

【Computational biology and Chemistry】介绍
英文名称:Computational biology and Chemistry

Computational Biology and Chemistry publishes original research papers and review articles in all areas of computational life sciences. High quality research contributions in the areas of nucleic acid and protein sequence research, molecular evolution, molecular genetics (functional genomics and proteomics), theory and practice of either biology-specific or chemical-biology-specific modeling, and structural biology of nucleic acids and proteins are particularly welcome. Exceptionally high quality research work in bioinformatics, systems biology, cybernetics, ecology, environmental sciences, computational pharmacology, metabolism, biomedical engineering, epidemiology, and statistical genetics will also be considered.
Review articles will generally be commissioned by the editors and should not be submitted to the journal without explicit invitation. However prospective authors are welcome to send a brief (one to three pages) synopsis which will be evaluated by the editors.

Welcome to the online submission and editorial system for Computational Biology and Chemistry.

  1. Analyzing functional similarity of protein sequences with discrete wavelet transform

  2. Computational biology and Chemistry,2005, 29, 220-228

    Qing XIONG  , Zhining Wen  , Ke Long Wang  , Menglong Li*  , Fu Sheng NIE 


    This paper applies discrete wavelet transform (DWT) with various protein substitution models to find functional similarity of proteins with low identity. A new metric, ‘S’ function, based on the DWT is proposed to measure the pair-wise similarity. We also develop a segmentation technique, combined with DWT, to handle long protein sequences. The results are compared with those using the pair-wise alignment and PSI-BLAST.